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Peripheral vascular disease (PVD) is a blood circulation disorder that causes the blood vessels outside of your heart and brain to narrow, block, or spasm. This can happen in your arteries or veins. PVD typically causes pain and fatige, often in your legs, and especially during exercise. The pain usually improves with rest. It can also affect the vessels that supply blood and oxygen to your: arms stomach and intestines kidneys In PVD, blood vessels become narrowed and blood flow decreases. This can be due to ,“hardening of the arteries,” or it can be caused by blood vessel spasms. In arteriosclerosis, plaques build up in a vessel and limit the flow of blood and oxygen to your organs and limbs.